David Luiz and Danny Drinkwater could both leave Chelsea
We take a look at some of the biggest deals that could go through before 5pm, with the likes of Manchester United, Arsenal, Newcastle, Burnley, Brighton and Chelsea all looking to do business.
Inter Milan are believed to have struck a 72 million fee for Lukaku after an on-off saga this summer.
Valencia striker Rodrigo has been the subject of an offer of more than 60 million from a mystery Premier League club, according to reports in Spain. The hotshot would be a fantastic addition to most squads.
Man City winger Leroy Sane has been heavily linked with a move to Bayern Munich. The German transfer window doesn't close until the end of the month though so this one could run and run.
Philippe Countinho could be set for a major move to north London with Arsenal and Tottenham both keen on the former Liverpool playmaker.
Christian Eriksen did look to be going to Manchester United before the deal broke down. With just a year left on his contract, Spurs could still look to cash in today.
Arsenal's on-off move for Kieran Tierney should be completed today after a fee was agreed last night for the Celtic defender.
David Luiz reportedly failed to report for Chelsea training yesterday as he eyes a shock 12million move to Arsenal. Everton are also monitoring the situation.
Former England goalkeeper Scott Carson, 34, could move to Premier League champions Manchester City from Derby on a season-long loan.
Finally, the long-standing Spurs target should complete a 25million move from Fulham.
Brighton have made a club record 28m bid for Genk midfielder Sander Berge, with Sheffield United having had a 22m bid rejected for the 21-year-old Norway international.
The big one. The Welsh star is unhappy at Real Madrid - could a Premier League club prize him away before the window shuts?
Can Burnley keep hold of star defender James Tarkowski amid huge interest from Leicester City as they look to replace Harry Maguire? It would take a big bid for the England man.
Leeds United star Kalvin Phillips is a target for Sheffield United as Chris Wilder looks to make late additions to his squad. Other Premier League clubs are also sniffing around the midfielder.
Moussa Sissako, of Paris Saint Germain, has been linked with Newcastle United and Brighton. The teenage defender is highly rated and would be a coup for either club.
Manchester United are willing to pay the 81m release clause of Athletic Bilbao and Spain forward Inaki Williams, 25, according to reports in Spain.
Linked with a big-money move away from Crystal Palace all summer. Reports he has handed in a transfer request as Everton and Arsenal keep tabs on the winger.
Danny Drinkwater could seal a move away from Chelsea today. Burnley, Norwich City and Brighton are all in the race to sign the 35million midfield flop.